The Schwebsite
About “me”
“Learn from yesterday, live for today, hope for tomorrow. The important thing is not to stop questioning.”
-Albert Einstein
Research Interests
I am an MD/PhD candidate at the Albert Einstein College of Medicine studying clonal competition in cancers of the blood (a.k.a. hematopoietic system), specifically myelodysplastic syndromes (MDS) and acute myeloid leukemias. I am currently modeling the systems-level properties and dynamics of the hematopoietic system that determine clonal expansion in del(5q) MDS patients; in particular, how the extrinsic effects of T-cell killing due to neoantigenicity of mutations and available hematopoietic stem cell niche space contribute to net fitness of a given clone.
My long-term interests lie in studying the greater system mechanisms that ensure that disease-causing clonal evolution does not occur for most of life despite the constant onslaught of mutations and genotoxic exposures, rather than mitigating advanced and highly evolved disease. I can only hope to help humanity in some way, perhaps through bridging the gap between healthcare and computer science, focusing on applied machine learning in healthcare; or maybe through some unexpected path that emerges, working on diverse projects across a variety of domains but connected by common threads in systems biology, evolutionary theory, network analysis, or information theory.
Publications
Piszczatowski RT*, Schwenger E*, Sundaravel S, Stein CM, Liu Y, Stanley P, Verma A, Zheng D, Seidel RD, Almo SC, Townley RA, Bülow HE, Steidl U. A glycan-based approach to cell characterization and isolation: Hematopoiesis as a paradigm. J Exp Med. 2022 Nov 7;219(11):e20212552. doi: 10.1084/jem.20212552. Epub 2022 Sep 6. _*Authors contributed equally to this work_
Schwenger E, Steidl U. An evolutionary approach to clonally complex hematologic disorders. Blood Cancer Discov. 2021 May;2(3):201-215. doi: 10.1158/2643-3230.BCD-20-0219. Epub 2021 Apr 15.
Ueda K, Kumari R, Schwenger E, Wheat JC, Bohorquez O, Narayanagari SR, Taylor SJ, Carvajal LA, Pradhan K, Bartholdy B, Todorova TI, Goto H, Sun D, Chen J, Shan J, Song Y, Montagna C, Xiong S, Lozano G, Pellagatti A, Boultwood J, Verma A, Steidl U. MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism. Cancer Cell. 2021 Apr 12;39(4):529-547.e7. doi: 10.1016/j.ccell.2021.02.006. Epub 2021 Mar 4.
Schwenger E, Reddy VP, Moorthy G, Sharma P, Tomkinson H, Masson E, Vishwanathan K. Harnessing Meta-analysis to Refine an Oncology Patient Population for Physiology-Based Pharmacokinetic Modeling of Drugs. Clin Pharmacol Ther. 2018 Feb;103(2):271-280. doi: 10.1002/cpt.917. Epub 2017 Nov 20.
Mbogning J, Pagé V, Burston J, Schwenger E, Fisher RP, Schwer B, Shuman S, Tanny JC. Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification. Nucleic Acids Res. 2015 Nov 16;43(20):9766-75. doi: 10.1093/nar/gkv837. Epub 2015 Aug 14.
Figures
Paintings
“Art washes away from the soul the dust of everyday life.” -Pablo Picasso
Notes
“Calculus required continuity, and continuity required the idea of the infinitely little, but nobody could discover what the infinitely little might be.”
-Bertrand Russell
Formulas
Euler’s formula
\(e^{i\pi}=-1\)
Taylor series raised to power of a matrix \(\mathbf{A}\)
\(e^{\mathbf{A}}=\mathbf{A}^0 + \mathbf{A}^1 + \dfrac{1}{2}\mathbf{A}^2 + \dfrac{1}{6}\mathbf{A}^3 + \dfrac{1}{24}\mathbf{A}^4 + ... + \dfrac{1}{n!}\mathbf{A}^n=\) stable matrix.
Schrödinger Equation, \(i\hslash\dfrac{\delta}{\delta t}|\psi\rangle=H|\psi\rangle\)
THe Schrödinger equation in all its glory:
\[\begin{aligned} i\hslash\dfrac{\delta}{\delta t}|\psi\rangle=H|\psi\rangle \end{aligned}\], where \(|\psi\rangle\) is the state of the system as a vector (of important parameters such as position and momentum).
Plots
Bifurcation plot \(f(x)=rx(1-x)\)
